In New York, the ambitious Dr. Jack Byron and his associate Gordon Mitchell present the research of his assistant Sam Rogers to the CEO and board of directors of a corporation to sponsor a scientific expedition to Borneo. The objective is to find a flower, Blood Orchid, that flourishes for a couple of weeks every seven years and could be a fountain of youth, prolonging the expectation of life of human beings. They are succeeded and once in Borneo, they realize that it is the raining season and there is no boat available to navigate on the river. They pay US$ 50,000.00 to convince Captain Bill Johnson and his partner Tran to sail to the location. After an accident in a waterfall, the survivors realize that a pack of anacondas have gathered for mating and their nest is nearby the plantation of Blood Orchid, which made them bigger and bigger.
本片是一部恐怖驚悚片，１９９７年賣座鉅片《大蟒蛇－神出鬼沒》的續篇，全片在斐濟拍攝，故事背景在婆羅洲的原始熱帶叢林，那兒有一種非常罕見的紅色蘭花品種血蘭花，據說能提煉出永保青春的血清。
有一批野心勃勃的科學家闖進危機四伏的叢林，尋找這種稀有的血蘭花，他們希望能找到青春的泉源，讓自己大大出名，也為他們的老闆賺大錢，但是他們很快就發現他們面對的不只是惡劣的天候和地形，而是更可怕的危險。
神秘的叢林中隱藏著一種致命的掠食者，牠捍衛著血蘭花的安全，只要有人膽敢闖入血蘭花所在的聖地，牠絕對不會讓他們活著離開…。
Anacondas.The.Hunt.For.The.Blood.Orchid.2004.1080p.WEB-DL.DD5.1.H264-LCDS.mkv
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